Stool and blood metabolomics in the metabolic syndrome: a cross-sectional study.

ABSTRACT:

Introduction/objectives

Changes in the stool metabolome have been poorly studied in the metabolic syndrome (MetS). Moreover, few studies have explored the relationship of stool metabolites with circulating metabolites. Here, we investigated the associations between stool and blood metabolites, the MetS and systemic inflammation.

Methods

We analyzed data from 1,370 participants of the KORA FF4 study (Germany). Metabolites were measured by Metabolon, Inc. (untargeted) in stool, and using the AbsoluteIDQ^® p180 kit (targeted) in blood. Multiple linear regression models, adjusted for dietary pattern, age, sex, physical activity, smoking status and alcohol intake, were used to estimate the associations of metabolites with the MetS, its components and high-sensitivity C-

SUBMITTER: Ponce-de-Leon M 

PROVIDER: S-EPMC11416374 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature