Longitudinal changes in cardiovascular disease-related proteins in welders.

ABSTRACT:

Objective

Occupational exposure to welding fumes is linked to a higher risk of cardiovascular disease; however, the threshold exposure level is unknown. Here, we aimed to identify changes in proteins associated with cardiovascular disease in relation to exposure to welding fumes.

Methods

Data were obtained from two timepoints six years apart for 338 non-smoking men (171 welders, 167 controls); of these, 174 (78 welders, 96 controls) had measurements available at both timepoints. Exposure was measured as personal respirable dust (adjusted for personal protective equipment), welding years, and cumulative exposure. Proximity extension assays were used to measure a panel of 92 proteins involved in cardiovascular processes in serum samples. Linear mixed models were used for longi

SUBMITTER: Dauter UM 

PROVIDER: S-EPMC11416389 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature