Sorafenib safety evaluation: Real-world analysis of adverse events from the FAERS database.

ABSTRACT:

Background

Sorafenib is approved for the targeted therapy of cancers such as liver cancer and renal cancer. Given its widespread use, drug-related adverse events have received attention, and the post-marketing regulatory link is crucial.

Objective

By using the FAERS database to mine the adverse events (AEs) related to sorafenib, comparing the association intensity of key AEs, and exploring potential drug-related AEs, it provides a reference for clinical medication.

Methods

Collect ADE data related to sorafenib in the FAERS database from 2006 to 2023. Standardize the data, and map adverse events to system organ classes and preferred terms. Analyze using various signal quantification techniques such as ROR, PRR, BCPNN, and MGPS.

Results

Among 18,520 adverse event

SUBMITTER: Ning L 

PROVIDER: S-EPMC11416516 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature