MCAUSE: Prioritizing mitochondrial targets that alleviate pancreatic cancer cell phenotypes.

ABSTRACT: Substantial changes in energy metabolism are a hallmark of pancreatic cancer. To adapt to hypoxic and nutrient-deprived microenvironments, pancreatic cancer cells remodel their bioenergetics from oxidative phosphorylation to glycolysis. This bioenergetic shift makes mitochondria an Achilles' heel. Since mitochondrial function remains essential for pancreatic cancer cells, further depleting mitochondrial energy production is an appealing treatment target. However, identifying effective mitochondrial targets for treatment is challenging. Here, we developed an approach, mitochondria-targeted cancer analysis using survival and expression (mCAUSE), to prioritize target proteins from the entire mitochondrial proteome. Selected proteins were further tested for their impact on pancreatic cancer ce

SUBMITTER: Murata D 

PROVIDER: S-EPMC11416656 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature