Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function.

ABSTRACT: Functional and phenotypic heterogeneity of dendritic cells (DCs) play crucial roles in facilitating the development of diverse immune responses essential for host protection. Here, we report that KDM5C, a histone lysine demethylase, regulates conventional or classical DC (cDC) and plasmacytoid DC (pDC) population heterogeneity and function. Mice deficient in KDM5C in DCs have increased proportions of cDC2Bs and cDC1s, which is partly dependent on type I interferon (IFN) and pDCs. Loss of KDM5C results in an increase in Ly6C^- pDCs, which, compared to Ly6C⁺ pDCs, have limited ability to produce type I IFN and more efficiently stimulate antigen-specific CD8 T cells. KDM5C-deficient DCs have increased expression of inflammatory genes, altered expression of lineage-specifi

SUBMITTER: Guak H 

PROVIDER: S-EPMC11416765 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature