The prognosis of HPV-associated metastatic pharyngeal patients by primary and distant site.

ABSTRACT:

Objectives

Human papillomavirus (HPV) positivity is a favorable prognostic factor in the general population of head and neck squamous cell carcinoma (HNSCC) patients. However, its impact on the survival of metastatic HNSCC of pharynx (mHNSC-P) patients is unclear. This study aims to investigate the associations between HPV status and survival in mHNSC-P patients.

Methods

735 mHNSC-P patients diagnosed at first presentation from 2010 to 2016 were retrieved from the Surveillance, Epidemiology and End Result database (SEER). Chi-Squared test, univariate and multivariate cox proportional hazards model, Kaplan-Meier analysis, and log-rank test were applied to compare HPV-positive and -negative mHNSC-P patients.

Result

Using univariate cox proportional hazards analysis, HPV

SUBMITTER: Wang J 

PROVIDER: S-EPMC11416869 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature