Expression Characteristics, Immune Signature, and Prognostic Value of the SOCS Family Identified by Multiomics Integrative Analysis in Liver Cancer.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a prevalent malignancy with a high mortality rate worldwide. Suppressor of cytokine signaling (SOCS) family members play important roles in the proliferation, metabolism, and immunity of HCC cells by regulating cytokines and growth factors. However, it remains uncertain whether the level of SOCS family members can affect the prognosis of HCC patients.

Aims

This study aimed to comprehensively assess the role and mechanisms of SOCS family members in the development of HCC and to guide clinical selection.

Methods

We investigated the expression levels of SOCS family genes in HCC patients and their associations with various clinicopathological characteristics. We also utilized a public database to analyze the changes in the expr

SUBMITTER: Dong Z 

PROVIDER: S-EPMC11416904 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature