Causal effects of air pollutants on lung function and chronic respiratory diseases: a Mendelian randomization study.

ABSTRACT:

Objectives

Our study aims to clarify the causality between air pollutants and lung function, chronic respiratory diseases, and the potential mediating effects of inflammatory proteins.

Method

We employed Mendelian Randomization (MR) analysis with comprehensive instrumental variables screening criteria to investigate the effects of air pollutants on lung function and chronic lung diseases. Our study incorporated genetic instruments for air pollutants, ensuring F-statistics above 20.86. A total of 18 MR analyses were conducted using the inverse-variance weighted approach, along with heterogeneity and pleiotropy tests to validate the results. Mediated MR analysis was utilized to evaluate the inflammatory proteins mediating the effects of air pollutants.

Result

MR

SUBMITTER: Li X 

PROVIDER: S-EPMC11416934 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature