The association of common autoimmune diseases with autoimmune thyroiditis: a two-sample Mendelian randomization study.

ABSTRACT:

Objective

Numerous observational and retrospective studies have demonstrated an association between Autoimmune Thyroiditis (AIT) and various systemic Autoimmune Diseases (AIDs). However, the causal relationship between them remains uncertain. This study aims to investigate the causal link between AIT and diverse types of AIDs utilizing the Mendelian Randomization (MR) method.

Method

We assessed the causal relationship between AIT and eight prevalent AIDs. Summary statistics from genome-wide association studies (GWAS) were sourced from the FinnGen biobank and IEU Open GWAS database. Two-sample MR analyses were conducted, with the primary statistical approach being the Inverse Variance Weighting (IVW) method. This was complemented by a series of sensitivity analyses, and the r

SUBMITTER: Zhang K 

PROVIDER: S-EPMC11416997 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature