Postoperative chemotherapy relative dose intensity and overall survival in patients with colon cancer.

ABSTRACT:

Purpose

Quantifying the association of chemotherapy relative dose intensity (RDI) with overall survival may enable supportive care interventions that improve chemotherapy RDI to estimate their magnitude of potential clinical benefit.

Methods

This cohort study included 533 patients with stage II-III colon cancer who initiated a planned regimen of 12 cycles of 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy. The primary exposure was chemotherapy RDI. The primary outcome was overall survival. Restricted cubic splines estimated hazard ratios (HR).

Results

Chemotherapy regimen RDI was associated with overall survival in an L-shaped pattern (linear P = 0.006; nonlinear P = 0.057); the risk of death was flat above 85% but increased linearly below 85%. For e

SUBMITTER: Brown JC 

PROVIDER: S-EPMC11417131 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature