Integrative analysis of the immunological significances of guanylate binding protein family genes in microsatellite stability colorectal cancer.

ABSTRACT:

Background

Microsatellite stability (MSS) colorectal cancer (CRC) has poor sensitivity to immunotherapy and its underlying mechanisms are still unclear. Guanylate binding proteins (GBPs) are a family of GTPase involving innate immune responses by providing defense against invading microbes and pathogens. However, the immunological significances of GBPs in MSS CRC remain unknown.

Methods

We utilized bioinformatic tools to comprehensively analysis the expression pattern, clinical relevance, prognostic value, biological function, and immunoregulation effect of distinct GBP members in MSS CRC.

Results

The expression of all seven GBPs in MSS samples are remarkably decreased compared to microsatellite instability-high (MSI-H) samples. Among them, GBP1/2/4/5 are obviously co

SUBMITTER: Wang X 

PROVIDER: S-EPMC11417218 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature