AGBL2 promotes renal cell carcinoma cells proliferation and migration via α-tubulin detyrosination.

ABSTRACT:

Background

AGBL2's role in tumorigenesis and cancer progression has been reported in several cancer studies, and it is closely associated with α-tubulin detyrosination. The roles of AGBL2 and α-tubulin detyrosination in renal cell carcinoma (RCC) pathogenesis remain unclear and require further investigation.

Methods

In this study, we conducted an analysis of AGBL2 expression differences between renal clear cell carcinoma tissues and normal tissues using data from The Cancer Genome Atlas (TCGA). We performed a comprehensive prognostic analysis of AGBL2 in Kidney Renal Clear Cell Carcinoma (KIRC) using univariate and multivariate Cox regression. Based on the results of the Cox analysis, we constructed a prognostic model to assess its predictive capabilities. Receiver Operating

SUBMITTER: Liu W 

PROVIDER: S-EPMC11417249 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature