Association of the systemic inflammation and anthropometric measurements with cancer risk: a prospective study in MJ cohort.

ABSTRACT:

Objective

To investigate the specific role of inflammation in the connection between obesity and the overall incidence of cancer.

Methods

A total of 356,554 participants in MJ cohort study were included. Systemic inflammation markers from blood samples and anthropometric measurements were determined using professional instruments. The Cox model was adopted to evaluate the association.

Results

Over a median follow-up of 8.2 years, 9,048 cancer cases were identified. For individual systemic inflammation biomarkers, the overall cancer risk significantly escalated as blood C-reactive protein (CRP) (hazard ratio (HR)=1.036 (1.017-1.054)) and globulin (GLO) (HR=1.128 (1.105-1.152)) levels increased, and as hemoglobin (HEMO) (HR=0.863 (0.842-0.884)), albumin (ALB) (HR=0.846

SUBMITTER: Bian Z 

PROVIDER: S-EPMC11417304 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature