Causal effect of serum matrix metalloproteinase levels on venous thromboembolism: a Mendelian randomization study.

ABSTRACT:

Objectives

Serum matrix metalloproteinase (MMP) levels are associated with cardiovascular diseases. However, the causal associations between serum levels of specific MMPs and venous thromboembolism (VTE) remain unclear. The present study sought to explore the causal relationship between serum MMP levels and VTE by using the Mendelian randomization (MR) method.

Methods

In this study 2-sample MR study, the exposure data on serum MMP levels were derived from genome-wide association studies involving 21,758 individuals from 13 cohorts of European descent. The outcome data on VTE, including deep vein thrombosis and pulmonary embolism, were derived from the FinnGen research project. The primary method used was the inverse-variance weighting method. The MR-Egger intercept test and

SUBMITTER: Han D 

PROVIDER: S-EPMC11417446 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature