Clinical and genetic associations of asymmetric apical and septal left ventricular hypertrophy.

ABSTRACT:

Aims

Increased left ventricular mass has been associated with adverse cardiovascular outcomes including incident cardiomyopathy and atrial fibrillation. Such associations have been studied in relation to total left ventricular hypertrophy, while the regional distribution of myocardial hypertrophy is extremely variable. The clinically significant and genetic associations of such variability require further study.

Methods and results

Here, we use deep learning-derived phenotypes of disproportionate patterns of hypertrophy, namely, apical and septal hypertrophy, to study genome-wide and clinical associations in addition to and independent from total left ventricular mass within 35 268 UK Biobank participants. Using polygenic risk score and Cox regression, we quantified the rela

SUBMITTER: Yuan V 

PROVIDER: S-EPMC11417484 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature