Predicting superagers: a machine learning approach utilizing gut microbiome features.

ABSTRACT:

Objective

Cognitive decline is often considered an inevitable aspect of aging; however, recent research has identified a subset of older adults known as "superagers" who maintain cognitive abilities comparable to those of younger individuals. Investigating the neurobiological characteristics associated with superior cognitive function in superagers is essential for understanding "successful aging." Evidence suggests that the gut microbiome plays a key role in brain function, forming a bidirectional communication network known as the microbiome-gut-brain axis. Alterations in the gut microbiome have been linked to cognitive aging markers such as oxidative stress and inflammation. This study aims to investigate the unique patterns of the gut microbiome in superagers and to develop mac

SUBMITTER: Kim HE 

PROVIDER: S-EPMC11417495 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature