Characterization of 2-((4-(chloromethyl)benzoyl)oxy)benzoate acid for analgesic tablet dosage form formulation.

ABSTRACT: The 2-((4-(chloromethyl)benzoyl)oxy)benzoic acid (4CH₂Cl) is a potential analgesic compound derived from salicylic acid and 4-chloromethyl benzoyl chloride. Characterization required 4CH₂Cl for the formulation of tablet dosage forms. This study aims investigate the effect of SSG, PVP-K30, and the combination of SSG*PVP K-30 on the formulation of 4CH₂Cl tablets. Additionally, this study aimed to obtain the optimum 4CH₂Cl tablet composition. The experiment followed the two-factor simplex lattice design and direct compression method. The analgesic activity of 4CH₂Cl in the optimal tablet was investigated using the hot-plate methods. The ANOVA of linear models is acceptable and the polynomial coefficients of quadratic models are similar to

SUBMITTER: Hadinugroho W 

PROVIDER: S-EPMC11417518 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature