Association of single nucleotide polymorphisms and gene-environment interactions with major depressive disorder in Chinese.

ABSTRACT: We conducted a case-control study to investigate the effects of genetics and gene-environment interactions on major depressive disorders (MDD) in the Chinese population. Using targeted-exome sequencing, we included 984 patients with MDD and 508 healthy controls in our study. A logistic regression model was employed to analyze the association between single nucleotide polymorphisms (SNPs) and MDD. Additionally, a linear regression model was utilized to examine the associations between (1) gene-environment interaction and the 17-item Hamilton Depression Rating Scale, (2) SNPs and the Beck Scale for Suicide Ideation-Chinese version, and gene-environment interaction and the Beck scale for suicide ideation-Chinese version. The association analysis between SNPs and MDD revealed that the followin

SUBMITTER: Luan D 

PROVIDER: S-EPMC11417526 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature