Characterization of isoniazid resistance and genetic mutations in isoniazid-resistant and rifampicin-susceptible Mycobacterium tuberculosis in China.

ABSTRACT:

Background

Patients with tuberculosis resistant to isoniazid but susceptible to rifampicin (H^r-R^s TB) remain a neglected demographic, despite a high disease burden and poor outcomes of these patients. The aim of this study was to investigate the characteristics of isoniazid-resistance-related mutations in Mycobacterium tuberculosis and resistance rates to drugs included in WHO-recommended regimens for H^r-R^s patients.

Methods

Mycobacterium tuberculosis isolates (n = 4922) obtained from national tuberculosis drug-resistance surveillance were subjected to whole-genome sequencing to identify H^r-R^s strains. The minimal inhibitory concentrations (MICs) were established for the H^r-R

SUBMITTER: Liu D 

PROVIDER: S-EPMC11417578 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature