A non-invasive measure of bone growth in mammals: Validating urinary CTX-I as a bone resorption marker through long-bone growth velocity in bonobos.

ABSTRACT: Assessing bone growth trajectories in mammals is crucial for understanding life history dynamics, but the quantification of bone growth in natural settings can be challenging. Bone resorption markers that can be measured in urine, such as C-telopeptide of type I collagen (CTX-I), offer a non-invasive solution to assess bone growth. Although measurement of urinary CTX-I levels has been applied extensively in human studies, its use in other species is so far limited to a few clinical studies. To validate urinary CTX-I as a bone resorption marker under less controlled conditions, we investigated within-individual day-to-day variation, diurnal patterns, and sex and age-specific variation in zoo-housed bonobos (Pan paniscus). We then also correlated urinary CTX-I levels with forearm grow

SUBMITTER: Behringer V 

PROVIDER: S-EPMC11417956 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature