Cyclohexanediamine Triazole (CHDT) Functionalization Enables Labeling of Target Molecules with Al¹⁸F/⁶⁸Ga/¹¹¹In.

ABSTRACT: The Al¹⁸F-labeling approach offers a one-step access to radiofluorinated biomolecules by mimicking the labeling process for radiometals. Although these labeling conditions are considered to be mild compared to classic radiofluorinations, improvements of the chelating units have led to the discovery of (±)-H₃RESCA, which allows Al¹⁸F-labeling already at ambient temperature. While the suitability of (±)-H₃RESCA for functionalization and radiofluorination of proteins is well established, its use for small molecules or peptides is less explored. Herein, we advanced this acyclic pentadentate ligand by introducing an alkyne moiety for the late-stage functionalization of biomolecules via click chemistry. We show

SUBMITTER: Sihver W 

PROVIDER: S-EPMC11417994 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature