Predictive value of metabolic profiling in cardiovascular risk scores: analysis of 75 000 adults in UK Biobank.

ABSTRACT:

Background

Metabolic profiling (the extensive measurement of circulating metabolites across multiple biological pathways) is increasingly employed in clinical care. However, there is little evidence on the benefit of metabolic profiling as compared with established atherosclerotic cardiovascular disease (CVD) risk scores.

Methods

UK Biobank is a prospective study of 0.5 million participants, aged 40-69 at recruitment. Analyses were restricted to 74 780 participants with metabolic profiling (measured using nuclear magnetic resonance) and without CVD at baseline. Cox regression was used to compare model performance before and after addition of metabolites to QRISK3 (an established CVD risk score used in primary care in England); analyses derived three models, with metabolites

SUBMITTER: Jin D 

PROVIDER: S-EPMC11418003 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature