Dietary fibers boost gut microbiota-produced B vitamin pool and alter host immune landscape.

ABSTRACT:

Background

Dietary fibers can alter microbial metabolic output in support of healthy immune function; however, the impact of distinct fiber sources and immunomodulatory effects beyond short-chain fatty acid production are underexplored. In an effort to discern the effects of diverse fibers on host immunity, we employed five distinct rodent diets with varying fiber content and source in specific-pathogen-free, gnotobiotic (containing a 14-member synthetic human gut microbiota), and germ-free mice.

Results

Broad-scale metabolomics analysis of cecal contents revealed that fiber deprivation consistently reduced the concentrations of microbiota-produced B vitamins. This phenomenon was not always explained by reduced biosynthesis, rather, metatranscriptomic analyses pointed toward

SUBMITTER: Grant ET 

PROVIDER: S-EPMC11418204 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature