Decitabine enclosed biotin-zein conjugated nanoparticles: synthesis, characterization, <i>in vitro</i> and <i>in vivo</i> evaluation.

ABSTRACT: Aim: This study focuses on biotinylated nanocarriers designed to encapsulate amphiphilic molecules with self-biodegradable properties for enhanced drug delivery.Methods: Biotin-zein conjugated nanoparticles were synthesized and tested in C6 cell lines to evaluate their viability and cellular uptake. Optimization was achieved using a a central composite design. The nanoparticles underwent thermogravimetric analysis, and their pharmacokinetics and biodistribution were also studied.Results: The optimized nanoparticles displayed 96.31% drug encapsulation efficiency, a particle size of 95.29 nm and a zeta potential of -17.7 mV. These nanoparticles showed increased cytotoxicity and improved cellular uptake compared with free drugs. Thermogravimetric analysis revealed that th

SUBMITTER: Mhaske A 

PROVIDER: S-EPMC11418219 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature