Beyond MitoCarta-expanding the list of candidate proteins involved in mitochondrial functions using a biological network approach.

ABSTRACT: Mitochondrial diseases are the result of pathogenic variants in genes involved in the diverse functions of the mitochondrion. A comprehensive list of mitochondrial genes is needed to improve gene prioritization in the diagnosis of mitochondrial diseases and development of therapeutics that modulate mitochondrial function. MitoCarta is an experimentally derived catalog of proteins localized to mitochondria. We sought to expand this list of mitochondrial proteins to identify proteins that may not be localized to the mitochondria yet perform important mitochondrial functions. We used a computational approach to assign statistical significance to the overlap between STRING database gene network neighborhoods and MitoCarta proteins. Using a data-driven stringent significance threshold, 2059 pro

SUBMITTER: Leyfer D 

PROVIDER: S-EPMC11418223 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature