Exploring the Correlation Between Hypoxia, HIF1A Variants, and Breast Cancer in Different Ethnicities, and Bangladeshi Women: Through ELISA and Integrative Multi-Omics Analysis.

ABSTRACT:

Background

Hypoxia, a condition where there is a lack of oxygen, is known to play a role in cancer progression.

Objective

This study investigates the correlation between HIF1A gene-altered expression and hypoxia in Bangladeshi breast cancer (BC) cases and TCGA_BC datasets.

Design

This case-control study compares BC cases to healthy controls to understand the relationship between gene changes and cancer.

Method

This study used advanced analysis methods to examine the transcriptional landscape of BC, and quantitatively assessed its correlation using integrated multi-omics analysis.

Results

In Bangladeshi BC cases, the T allele of HIF1A rs1154946 correlates notably (P-value < .001) with BC incidence. ELISA results confirmed a significan

SUBMITTER: Islam MS 

PROVIDER: S-EPMC11418304 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature