Deep and unbiased proteomics, pathway enrichment analysis, and protein-protein interaction of biomarker signatures in migraine.

ABSTRACT:

Background

Currently, there are no biomarkers for migraine.

Objectives

We aimed to identify proteomic biomarker signatures for diagnosing, subclassifying, and predicting treatment response in migraine.

Design

This is a cross-sectional and longitudinal study of untargeted serum and cerebrospinal fluid (CSF) proteomics in episodic migraine (EM; n = 26), chronic migraine (CM; n = 26), and healthy controls (HC; n = 26).

Methods

We developed classification models for biomarker identification and natural clusters through unsupervised classification using agglomerative hierarchical clustering (AHC). Pathway analysis of differentially expressed proteins was performed.

Results

Of 405 CSF proteins, the top five proteins that discriminated betw

SUBMITTER: Woldeamanuel YW 

PROVIDER: S-EPMC11418313 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature