Systemic oxidative stress levels during the course of pregnancy: Associations with exposure to air pollutants.

ABSTRACT: Increased systemic oxidative stress, implicated in adverse pregnancy outcomes for both mothers and fetuses, has been associated with gestational exposure to air pollutants such as polycyclic aromatic hydrocarbons (PAHs), fine particulate matter (PM_2.5), and nitrogen dioxide (NO₂). However, it is unclear whether exposure to pollutants at levels below the current air quality standards can increase oxidative stress in pregnant women. In a cohort of 305 pregnant persons residing in western New York, we examined the association between exposure to PM_2.5, NO₂, and PAHs (measured as urinary 1-hydroxypyrene) and urinary biomarkers of oxidative stress (malondialdehyde [MDA] and 8-hydroxy-2'-deoxyguanosine [8-OHdG]) measured in each trimester. After contro

SUBMITTER: Wang X 

PROVIDER: S-EPMC11418402 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature