Drug classes affecting intracranial aneurysm risk: Genetic correlation and Mendelian randomization.

ABSTRACT:

Introduction

There is no non-invasive treatment to prevent aneurysmal subarachnoid hemorrhage (ASAH) caused by intracranial aneurysm (IA) rupture. We aimed to identify drug classes that may affect liability to IA using a genetic approach.

Patients and methods

Using genome-wide association summary statistics we calculated genetic correlation between unruptured IA (N = 2140 cases), ASAH (N = 5140) or the combined group, and liability to drug usage from 23 drug classes (N up to 320,000) independent of the risk factor high blood pressure. Next, we evaluated the causality and therapeutic potential of correlated drug classes using three different Mendelian randomization frameworks.

Results

Correlations with IA were found for antidepressants, paracetamol

SUBMITTER: Ruigrok YM 

PROVIDER: S-EPMC11418413 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature