Autoantibodies, cutaneous subset and immunosuppressants contribute to the cancer risk in systemic sclerosis.

ABSTRACT:

Objective

Systemic sclerosis (SSc) is associated with an increased risk of cancer. We aimed to assess the prevalence of cancer in our cohort and to explore possible associations with clinical, immunological and treatment characteristics.

Methods

Our retrospective monocentric cohort study of patients with SSc recorded prevalent and incident cases of malignancy, including those diagnosed within 3 years of the SSc onset (defined as cancer-associated scleroderma) and sought associations with the clinical characteristics and the serum autoantibody profiling performed using RNA and protein immunoprecipitation, Western-blot, immunoblot and ELISA at the time of SSc diagnosis, prior to any specific treatment.

Results

Among 290 patients with SSc, the overall prevalence of cance

SUBMITTER: Tonutti A 

PROVIDER: S-EPMC11418480 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature