MRI hypoperfusion as a determinant of cognitive impairment in adults with Moyamoya angiopathy.

ABSTRACT:

Introduction

In Moyamoya angiopathy (MMA), mechanisms underlying cognitive impairment remain debated. We aimed to assess the association of cognitive impairment with the degree and the topography of cerebral hypoperfusion in MMA.

Methods

A retrospective analysis of neuropsychological and perfusion MRI data from adults with MMA was performed. Ischemic and haemorrhagic lesion masks were created to account for cerebral lesions in the analysis of cerebral perfusion. Whole brain volume of hypoperfused parenchyma was outlined on perfusion maps using different Tmax thresholds from 4 to 12 s. Regional analysis produced mean Tmax values at different regions of interest. Analyses compared perfusion ratios in patients with and without cognitive impairment, with multivariable logistic r

SUBMITTER: Giroud M 

PROVIDER: S-EPMC11418512 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature