Characterisation and outcomes of different subsets of low disease activity states in patients with systemic lupus erythematosus.

ABSTRACT:

Objectives

The lupus low disease activity state (LLDAS) allows for certain clinical and/or serological activity of SLE, provided overall disease activity does not exceed predefined cut-offs. This study aimed to evaluate the outcomes of patients who achieved LLDAS with clinical activity, serological activity only or neither clinical nor serological activity.

Methods

Patients with SLE enrolled in a prospective multinational cohort from March 2013 to December 2020 who were in LLDAS at least once were included. Visits that fulfilled both LLDAS and Definition of Remission in SLE (DORIS) criteria were excluded.

Results

2099 patients were included, with median follow-up of 3.5 (IQR 1.3-5.8) years. At 6150 visits, patients were in LLDAS but not DORIS criteria; of these 1280 (

SUBMITTER: Hao Y 

PROVIDER: S-EPMC11418568 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature