Multiancestry transferability of a polygenic risk score for diverticulitis.

ABSTRACT:

Objective

Polygenic risk scores (PRS) for diverticular disease must be evaluated in diverse cohorts. We sought to explore shared genetic predisposition across the phenome and to assess risk stratification in individuals genetically similar to European, African and Admixed-American reference samples.

Methods

A 44-variant PRS was applied to the All of Us Research Program. Phenome-wide association studies (PheWAS) identified conditions linked with heightened genetic susceptibility to diverticular disease. To evaluate the PRS in risk stratification, logistic regression models for symptomatic and for severe diverticulitis were compared with base models with covariates of age, sex, body mass index, smoking and principal components. Performance was assessed using area under

SUBMITTER: Ueland TE 

PROVIDER: S-EPMC11418579 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature