Thiol-selective native grafting from polymerization for the generation of protein-polymer conjugates.

ABSTRACT: Protein-polymer conjugates combine properties of biopolymers and synthetic polymers, such as specific bioactivity and increased stability, with great benefits for various applications from catalysis to biomedicine. Furthermore, polymer conjugation can mimic important posttranslational modifications of proteins such as glycosylation. There are typically two approaches to create protein-polymer conjugates: the protein is functionalized in advance with an initiator for a grafting-from method or a previously produced polymer is conjugated to the protein via a grafting-to method. In this study, we present a new approach that uses native proteins and allows for direct grafting-from using a thiol-induced, light-activated controlled radical polymerization (TIRP) that is

SUBMITTER: Feldhof MI 

PROVIDER: S-EPMC11418805 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature