Development and validation of a mitotic catastrophe-related genes prognostic model for breast cancer.

ABSTRACT:

Background

Breast cancer has become the most common malignant tumor in women worldwide. Mitotic catastrophe (MC) is a way of cell death that plays an important role in the development of tumors. However, the exact relationship between MC-related genes (MCRGs) and the development of breast cancer is still unclear, and further research is needed to elucidate this complexity.

Methods

Transcriptome data and clinical data of breast cancer were downloaded from the Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) database. We identified differential expression of MCRGs by comparing tumor tissue with normal tissue. Subsequently, we used COX regression analysis and LASSO regression analysis to construct the prognosis risk model of MCRGs. Kaplan-Meier survival

SUBMITTER: Wang S 

PROVIDER: S-EPMC11418815 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature