Expression of microRNA-155 in thalassemic erythropoiesis.

ABSTRACT:

Background

Ineffective erythropoiesis (IE) is the primary cause of anemia and associated pathologies in β-thalassemia. The characterization of IE is imbalance of erythroid proliferation and differentiation, resulting in increased erythroblast proliferation that fails to differentiate and gives rise to enucleate RBCs. MicroRNAs (miRs) are known to play important roles in hematopoiesis. miR-155 is a multifunctional molecule involved in both normal and pathological hematopoiesis, and its upregulation is observed in patients with β-thalassemia/HbE. However, the expression and function of miR-155, especially in β-thalassemia, have not yet been explored.

Methods

To study miR-155 expression in thalassemia, erythroblast subpopulations, CD45-CD71⁺Ter-1

SUBMITTER: Penglong T 

PROVIDER: S-EPMC11418816 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature