A novel biomechanical model of the mouse forelimb predicts muscle activity in optimal control simulations of reaching movements.

ABSTRACT: Mice are key model organisms in neuroscience and motor systems physiology. Fine motor control tasks performed by mice have become widely used in assaying neural and biophysical motor system mechanisms. Although fine motor tasks provide useful insights into behaviors which require complex multi-joint motor control, there is no previously developed physiological biomechanical model of the adult mouse forelimb available for estimating kinematics nor muscle activity or kinetics during behaviors. Here, we developed a musculoskeletal model based on high-resolution imaging of the mouse forelimb that includes muscles spanning the neck, trunk, shoulder, and limbs. Physics-based optimal control simulations of the forelimb model were used to estimate in vivo muscle activity present when constr

SUBMITTER: Gilmer JI 

PROVIDER: S-EPMC11418950 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature