Preoptic area controls sleep-related seizure onset in a genetic epilepsy mouse model.

ABSTRACT: In genetic and refractory epileptic patients, seizure activity exhibits sleep-related modulation/regulation and sleep and seizure are intermingled. In this study, by using one het Gabrg2 ^Q390X KI mice as a genetic epilepsy model and optogenetic method in vivo, we found that subcortical POA neurons were active within epileptic network from the het Gabrg2 ^Q390X KI mice and the POA activity preceded epileptic (poly)spike-wave discharges(SWD/PSDs) in the het Gabrg2 ^Q390X KI mice. Meanwhile, as expected, the manipulating of the POA activity relatively altered NREM sleep and wake periods in both wt and the het Gabrg2 ^Q390X KI mice. Most importantly, the short activation of epileptic cortica

SUBMITTER: Potesta CV 

PROVIDER: S-EPMC11418963 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature