Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples.

ABSTRACT: The prediction of phenotypes from ancient humans has gained interest due to its potential to investigate the evolution of complex traits. These predictions are commonly performed using polygenic scores computed with DNA information from ancient humans along with genome-wide association studies (GWAS) data from present-day humans. However, numerous evolutionary processes could impact the prediction of phenotypes from ancient humans based on polygenic scores. In this work we investigate how natural selection impacts phenotypic predictions on ancient individuals using polygenic scores. We use simulations of an additive trait to analyze how natural selection impacts phenotypic predictions with polygenic scores. We simulate a trait evolving under neutrality, stabilizing selection and directiona

SUBMITTER: Anorve-Garibay V 

PROVIDER: S-EPMC11419050 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature