The N-terminus of the <i>Chlamydia trachomatis</i> effector Tarp engages the host Hippo pathway.

ABSTRACT: Chlamydia trachomatis is an obligate, intracellular Gram-negative bacteria and the leading bacterial STI in the United States. Chlamydia's developmental cycle involves host cell entry, replication within a parasitophorous vacuole called an inclusion, and induction of host cell lysis to release new infectious particles. During development, Chlamydia manipulates the host cell biology using various secreted bacterial effectors. The early effector Tarp is important for Chlamydia entry via its well-characterized C-terminal region which can polymerize and bundle F-actin. In contrast, not much is known about the function of Tarp's N-terminus (N-Tarp), though this N-terminal region is present in many Chlamydia species. To address this, we use Drosophila melano

SUBMITTER: Aranjuez GF 

PROVIDER: S-EPMC11419093 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature