The <i>Drosophila</i> Estrogen-Related Receptor promotes triglyceride storage within the larval fat body.

ABSTRACT: The Estrogen-Related Receptor (ERR) family of nuclear receptors (NRs) serve key roles in coordinating triglyceride (TAG) accumulation with juvenile growth and development. In both insects and mammals, ERR activity promotes TAG storage during the post-embryonic growth phase, with loss-of-function mutations in mouse Esrra and Drosophila melanogaster dERR inducing a lean phenotype. However, the role of insect ERRs in controlling TAG accumulation within adipose tissue remains poorly understood, as previous transcriptomic and metabolomic studies relied on whole animal analyses. Here we address this shortcoming by using tissue-specific approaches to examine the role of dERR in regulating lipid metabolism within the Drosophila larval fat body. We find that dERR autonomously p

SUBMITTER: Fasteen TD 

PROVIDER: S-EPMC11419140 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature