Protection of double-Holliday junctions ensures crossing over during meiosis.

ABSTRACT: Chromosomal linkages formed through crossover recombination are essential for accurate segregation of homologous chromosomes during meiosis¹. The DNA events of recombination are linked to structural components of meiotic chromosomes². Imperatively, the biased resolution of double-Holliday junction intermediates (dHJs) into crossovers^3,4 occurs within the synaptonemal complex (SC), the meiosis-specific structure that mediates end-to-end synapsis of homologs during the pachytene stage^5,6. However, the SC's roles in crossover-specific dHJ resolution remains unclear. Here, we show that key SC components function through dependent and interdependent relationships to protect dHJs from aberrant "dissolution" into noncrossover products. Conditional ablat

SUBMITTER: Tang S 

PROVIDER: S-EPMC11419148 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature