Initial Experience of Metabolic Imaging with Hyperpolarized [1-¹³C]pyruvate MRI in Kidney Transplant Patients.

ABSTRACT:

Background

Kidney transplant is the treatment of choice for patients with end-stage renal disease. Early detection of allograft injury is important to delay or prevent irreversible damage.

Purpose

To investigate the feasibility of hyperpolarized (HP) [1-¹³C]pyruvate MRI for assessing kidney allograft metabolism.

Study type

Prospective.

Subjects

6 participants (mean age, 45.2 ± 12.4 years, 2 females) scheduled for kidney allograft biopsy and 5 patients (mean age, 59.6 ± 10.4 years, 2 females) with renal cell carcinoma (RCC).

Field strength/sequence

3 Tesla, T2-weighted fast spin echo, multi-echo gradient echo, single shot diffusion-weighted echo-planar imaging, and time-resolved HP ¹³C metabolite-selective imaging.

Assessment

SUBMITTER: Liu X 

PROVIDER: S-EPMC11419194 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature