Human Papillomavirus-Associated Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

Human papillomavirus (HPV) is known to affect head and neck sites beyond the oropharynx, including the nasopharynx. Unlike HPV-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC), HPV-associated nasopharyngeal carcinoma (HPV+NPC) is not well characterized and the true prevalence in non-endemic regions is poorly described. Here, we sought to obtain a global point prevalence of HPV in NPC, stratified by geographic region.

Data sources

EMBASE, OVID Medline, and Web of Science were systematically searched for available evidence on September 21, 2022 for articles published between January 1, 1990 and September 21, 2022.

Review methods

We reviewed the literature for all studies examining NPC and HPV status in adult patients that provided a quantitative HP

SUBMITTER: Zhao BY 

PROVIDER: S-EPMC11419204 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature