Immune Cell Densities Predict Response to Immune Checkpoint-Blockade in Head and Neck Cancer.

ABSTRACT: Immune checkpoint blockade (ICB) is the standard of care for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), yet efficacy remains low. The current approach for predicting the likelihood of response to ICB is a single proportional biomarker (PD-L1) expressed in immune and tumor cells (Combined Positive Score, CPS) without differentiation by cell type, potentially explaining its limited predictive value. Tertiary Lymphoid Structures (TLS) have shown a stronger association with ICB response than PD-L1. However, their exact composition, size, and spatial biology in HNSCC remain understudied. A detailed understanding of TLS is required for future use as a clinically applicable predictive biomarker.

Methods

Pre-ICB tumor tissue sections were obtained from 9 responders

SUBMITTER: Ruiz-Torres DA 

PROVIDER: S-EPMC11419212 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature