Altered Cytokine Profile in Clinically Suspected Seronegative Autoimmune Associated Epilepsy.

ABSTRACT:

Background and objectives

Autoimmune-associated epilepsy (AAE), a condition which responds favorably to immune therapies but not traditional anti-seizure interventions, is emerging as a significant contributor to cases of drug-resistant epilepsy. Current standards for the diagnosis of AAE rely on screening for known neuronal autoantibodies in patient serum or cerebrospinal fluid. However, this diagnostic method fails to capture a subset of drug-resistant epilepsy patients with suspected AAE who respond to immunotherapy yet remain seronegative (snAAE) for known autoantibodies.

Methods

To identify potential biomarkers for snAAE, we evaluated the most comprehensive panel of assayed cytokines and autoantibodies to date, comparing patients with snAAE, anti-seizure medication (ASM

SUBMITTER: Motovilov K 

PROVIDER: S-EPMC11419235 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature