Sleep inertia drives the association of evening chronotype with psychiatric disorders: epidemiological and genetic evidence.

ABSTRACT: Evening chronotypes (a.k.a. "night-owls") are held to be at greater risk for psychiatric disorders. This is postulated to be due to delayed circadian timing increasing the likelihood of circadian misalignment in an early-oriented society. Circadian misalignment is known to heighten sleep inertia, the difficulty transitioning from sleep to wake characterized by low arousal and cognitive impairment, and evening chronotypes experience greater sleep inertia. Therefore, difficulty awakening may explain the relationship between evening chronotype and psychiatric disorders by acting as a biomarker of circadian misalignment. In analyzing the longitudinal incidence of psychiatric disorders in the UK Biobank (n = 496,820), we found that evening chronotype predicted increased incidence of majo

SUBMITTER: Burns AC 

PROVIDER: S-EPMC11419237 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature