Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression.

ABSTRACT: Alternative transcription start sites can affect transcript isoform diversity and translation levels. In a recently described form of gene regulation, coordinated transcriptional and translational interference results in transcript isoform-dependent changes in protein expression. Specifically, a long undecoded transcript isoform (LUTI) is transcribed from a gene-distal promoter, interfering with expression of the gene-proximal promoter. Although transcriptional and chromatin features associated with LUTI expression have been described, the mechanism underlying LUTI-based transcriptional interference is not well understood. Using an unbiased genetic approach followed by functional genomics, we uncovered that the Swi/Snf chromatin remodeling complex is required for co-transcriptional nucleos

SUBMITTER: Morse K 

PROVIDER: S-EPMC11419397 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature