Effect of long-term pharmacological treatments on Alzheimer disease: A systematic review and network meta-analysis.

ABSTRACT:

Background

To analyze and compare the pharmacological treatments for Alzheimer disease (AD), we will conduct a systematic review and network meta-analysis focusing on their efficacy and safety over a duration exceeding 1 year.

Methods

We searched the databases of PubMed, Scopus, EMBASE, Web of Science, the Cochrane Central Register of Controlled Trials, and CNKI until July 30, 2023, for randomized controlled trials (RCTs) evaluating pharmacological treatments for AD.

Results

Seventeen RCTs, comprising 7214 participants, investigated the efficacy of the following drugs: Donepezil, Rivastigmine, Galantamine, Memantine, Ginkgo biloba extract (EGb), Atorvastatin-calcium and Vitamin B in the treatment of AD. The network meta-analysis resulted indicated that placebo demonst

SUBMITTER: Deng X 

PROVIDER: S-EPMC11419515 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature