Sedentary and 21 gastrointestinal disorders: A Mendelian randomization study.

ABSTRACT: Sedentary behavior (SB) has been linked in the past by observational studies to gastrointestinal illnesses, although the exact cause of the link is still unknown. To deal with this problem, we carried out a Mendelian randomization (MR) study to thoroughly examine the connection between SB and common gastrointestinal illnesses. We selected instrumental variables representing the SB from the UK Biobank study, including watching television viewing, playing computer, and driving. In addition, we obtained genetic associations of 21 common gastrointestinal disorders from the FinnGen research. After adjusting for common risk factors associated with gastrointestinal diseases, we analyzed the independent association between genetic. Furthermore, we used the inverse-variance weighted (IVW) method in

SUBMITTER: Lin Y 

PROVIDER: S-EPMC11419558 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature